In the last years there is a strong interest for application of bioclimatic techniques and practices in urbanneighborhoods and open spaces. This paper presents a bioclimatic study of an open space in an urbanarea by the use of simulation tools giving emphasis on the replacement of conventional materials withcool materials. Routes linking traditional monuments in the Greek city of Florina are characterized ofdecreased human thermal comfort conditions during summer time. The employment of computationalfluid dynamics has contributed in the understanding of what interventions should be made on urbanpopulated routes in order to meet defined thermal related targets during the warmest day of the year.The proposed replacement of conventional materials by “cool” ones would result in the reduction of themean surface temperature by 3.52◦C while the mean maximum air temperature would be reduced by1.39◦C during noon of the warmest day.